Answering the narrow version, because the broad one does not have a single answer. The pharmacokinetics explain nearly every practical question asked here. Albumin binding above 99% slows clearance enough to make weekly dosing possible; a terminal half-life near a week means four to five weeks to steady state and therefore a four-week titration interval; subcutaneous bioavailability around 89% means injection site barely matters. Those three facts answer most timing questions before they are asked.

I would rather be corrected than agreed with, if it comes to it.

Dr.ReproEndo said:

The pharmacokinetics explain nearly every practical question asked here.

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.

pat_auckland said:

Two missed doses in three months, both for boring logistical reasons, and I cannot find a straight answer about what to do that is not a copy of a…

Same pattern here, and in the same order.

Clinical perspective, offered as context rather than as advice.

Missed dose question about a missed dose: I'm 2 days late on my injection. Should I take it now or wait until my regular day?

UPDATE: Called my provider — they said take it now and resume my regular schedule next week. Apparently being a few days late isn't a big deal as long as you don't double up.