Dr.Martinez said:

Routine calcitonin screening is not recommended and does more harm than good in this population — the false-positive rate is high and the workup is…

Thyroid cancer screening labs for thyroid monitoring — addressing the boxed warning concern with actual data:

Calcitonin level: 4.0 pg/mL (normal <10). Checked at baseline, month 6, and month 12. Rock stable, no upward trend.

Thyroid ultrasound: normal, no nodules at month 12.

The MTC risk from rodent studies has not been confirmed in human post-marketing data across millions of patient-years. The boxed warning is a regulatory precaution based on animal data. While monitoring is prudent, the clinical risk appears to be negligible.

Dr.Martinez said:

Routine calcitonin screening is not recommended and does more harm than good in this population — the false-positive rate is high and the workup is…

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

This one has a reasonably settled answer, so here it is. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

SarahChen_PharmD said:

Thyroid cancer screening labs for thyroid monitoring — addressing the boxed warning concern with actual data: Calcitonin level: 4.0 pg/mL (normal…

Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.