🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationVitamin D optimization on GLP-1 — testing and dosing guide

Vitamin D optimization on GLP-1 — testing and dosing guide

Dr.Martinez Tue, May 12, 2026 at 7:12 AM 8 replies 422 viewsPage 1 of 2
Dr.Martinez
Medical Advisor
3,891
28,456
Nov 2023
Boston, MA
Online
May 12, 2026 at 7:12 AM#1

This is the version of the explanation I wish somebody had given me, written down before I forget what confused me. It is about micronutrient cover, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium. Two of those are worth testing rather than guessing because the tests are cheap and the symptoms overlap with everything else — ferritin and B12. The rest a decent multivitamin covers, and there is no benefit in megadosing any of them.

The condition it depends on

The caveat that iron should be tested before supplementing, not after. Supplementing iron into normal stores is unpleasant at best and harmful in haemochromatosis.

The practical version

Cheap and worth having: ferritin, B12, vitamin D. Everything else on the deficiency list is adequately covered by a standard multivitamin at ordinary doses.

What I am not sure about

So the question, as narrowly as I can put it: which deficiencies actually show up when intake drops this far, and which are worth testing rather than supplementing blind. Tell me what I have not thought of.

— Dr.Martinez · corrections welcome and will be edited into this post with credit
4 24AttorneyGrant, DebRD_ATL, KristenIndy and 1 other
Reply Quote Save Share Report
Dr.RenalNash
VIP Member
1,234
7,890
Mar 2024
Nashville, TN
May 12, 2026 at 8:37 AM#2
Dr.Martinez said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Blood count monitoring for micronutrients: my doctor noticed my MCV (mean corpuscular volume) trending up at month 6: 90 → 96 fL. This flagged potential B12 or folate deficiency.

Sure enough, B12 had dropped from 620 to 340 pg/mL. Started B12 injections monthly and MCV normalized within 2 months. GLP-1 agonists can impair B12 absorption — this is a real clinical concern that deserves routine monitoring.

3 23pam_stl, wei_SG, cory_ATX
Reply Quote Save Share Report
HPLC_Greg
Senior Member
1,890
8,901
Feb 2024
Research Triangle, NC
May 12, 2026 at 10:02 AM#3
Dr.Martinez said:
A sustained drop to 1,100 or 1,200 calories reliably under-delivers a predictable set: B12, vitamin D, iron, folate, zinc and magnesium.

Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly:

  • B12: Can drop due to reduced GI absorption. Mine went from 650 to 380 — now supplementing.
  • Iron/Ferritin: Reduced food intake = reduced iron. Ferritin dropped from 67 to 24. Supplementing.
  • Vitamin D: Was already low (18 ng/mL), now taking 5000 IU daily.
  • Folate: Stable, no issues.
  • Zinc: Slightly low, added a multivitamin with zinc.

Nutritional deficiencies are a real risk when you're eating significantly less. Don't skip your labs!

Last edited: May 12, 2026 at 4:02 PM
2 22RetaRick_CA, JenPlateau
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
TrialTracker_MD
Senior Member
2,345
15,678
Jan 2024
Maryland
May 12, 2026 at 11:27 AM#4
HPLC_Greg said:
Vitamin and mineral labs to check while on micronutrients — my doctor orders these quarterly: B12: Can drop due to reduced GI absorption.

Iron studies on micronutrients — important especially for women:

MarkerBaselineMonth 6After Supplementation
Ferritin792254
Iron1095982
TIBC334404334
Transferrin Sat28%19%25%

My ferritin cratered at month 6 from reduced dietary intake. Iron bisglycinate 36mg with vitamin C brought it back up. Don't wait for anemia symptoms — test proactively.

Last edited: May 12, 2026 at 4:27 PM
1 21Dr.PulmRoch
Reply Quote Save Share Report
B12Beth
Member
289
890
Oct 2024
Maryland
May 12, 2026 at 7:42 PM#5
Dr.RenalNash said:
Blood count monitoring for micronutrients: my doctor noticed my MCV (mean corpuscular volume) trending up at month 6: 90 → 96 fL.

This matches mine closely enough to be worth saying so out loud.

Last edited: May 12, 2026 at 10:42 PM
50 20pam_columbus, nick_SD_fit, ben_calgary and 47 others
Reply Quote Save Share Report

Similar Threads

Protein requirements on GLP-1: systematic review of RDA vs optimal intake8 replies
Micronutrient deficiency risk on GLP-1 — B12, D, iron, zinc, folate10 replies
High-protein meal plans for GLP-1 users — 1500-2000 kcal options9 replies
Meal prep Sunday — weekly high-protein recipes thread9 replies
Creatine monohydrate + GLP-1 — safety and lean mass preservation data14 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register