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Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationDigestive enzyme supplementation — does it help with GLP-1 GI symptoms?

Digestive enzyme supplementation — does it help with GLP-1 GI symptoms?

Dr.GutHealth Wed, May 6, 2026 at 7:23 PM 7 replies 544 viewsPage 1 of 2
Dr.GutHealth
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May 6, 2026 at 7:23 PM#1

My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat more.

The arithmetic that makes it tractable: reference weight in kg times 1.6 gives the target; divide by four for a per-sitting figure; then find four foods that hit that figure in a volume you can actually finish. Most people need two of the four to be liquid or semi-liquid early on.

What would genuinely help is knowing how people are hitting a protein target on a genuinely suppressed appetite, because volume is the binding constraint rather than willingness.

Not looking for reassurance. Looking for the part I have got wrong.

4 24VanRx_Mike, steve_okc, dave_SLC and 1 other
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anders_CPH
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May 6, 2026 at 8:28 PM#2

This one has a reasonably settled answer, so here it is. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

Last edited: May 7, 2026 at 12:28 AM
3 23MariaRD, AussieAnna, BethLabQueen
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Dr.PeteFamMed
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May 6, 2026 at 9:33 PM#3
anders_CPH said:
The RDA is the wrong reference and it is worth understanding why.

True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

2 22LindaRN_retired, tommy_boulder
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amy_econ_NJ
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May 6, 2026 at 10:39 PM#4
Dr.GutHealth said:
My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat…

This matches mine closely enough to be worth saying so. Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

Ask again with the specifics and you will get a better answer than this one.

1 21gary_naperville
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carl_compliance
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May 7, 2026 at 4:55 AM#5

From the other side of the consultation, briefly.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass259 lbs229 lbs196 lbs
Fat mass99 lbs79 lbs46 lbs
Lean mass152 lbs154 lbs153 lbs
Body fat %44%34%25%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

50 20dave_SLC, FDA_TrackerJim, ricardo_MIA and 47 others
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