Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

JenPlateau said:

Worth answering the question that was asked rather than the one behind it.

Adding the part of the answer the thread has not reached. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

One thing that is still open after JenPlateau’s answer:

What would you measure differently if you were starting again?

josh_phd_bmore said:

Practical: whatever you change, write down the date and the reason.

I read this differently from josh_phd_bmore, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.