Adding the numbers, since they settle part of this. A quick sanity check on any figure quoted here: is it mean or median, is it intention-to-treat or completers, and what was the comparator. Three questions, and they resolve most disagreements in these threads.
A narrower follow-up, since the general answer is now clear:
Whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be?
quinn_sf said:A quick sanity check on any figure quoted here: is it mean or median, is it intention-to-treat or completers, and what was the comparator.
Coming at quinn_sf’s question from a different direction. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.
Happy to go further on any of that.
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Front-loading was the answer. Same total intake, same drug, but two thirds of the protein before midday and I am hitting the target most days now.
andrew_nyc said:The gap between trial results and real-world results is consistent and it is not fraud.
Agreed on the target, with the caveat that reference weight and current weight are different numbers. Using current weight at the start of a large loss produces a target that is both unachievable and unnecessary.