🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationEating out on GLP-1 — 12 month update

Eating out on GLP-1 — 12 month update

marcus_mpls Thu, May 15, 2025 at 10:55 PM 10 replies 1,466 viewsPage 1 of 2
This thread is more than 12 months old. Information may be outdated. Consider searching for more recent discussions.
marcus_mpls
Member
234
1,123
Nov 2024
Minneapolis, MN
May 15, 2025 at 10:55 PM#1

My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat more.

So the question, as narrowly as I can put it: whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be.

Practical detail welcome, however dull — the duller the better.

35 5bbq_ray_KC, oliver_london, tane_welly and 32 others
Reply Quote Save Share Report
InsuranceTom
Senior Member
1,345
7,890
Mar 2024
Connecticut
May 15, 2025 at 11:18 PM#2

Short answer first, then the reasoning. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

34 4lucas_SP_BR, lisa_labSD, adam_van and 31 others
Reply Quote Save Share Report
sean_dublin
Member
212
890
Nov 2024
Dublin, IE
May 15, 2025 at 11:41 PM#3
InsuranceTom said:
The RDA is the wrong reference and it is worth understanding why.

Agreed on the target, with the caveat that reference weight and current weight are different numbers. Using current weight at the start of a large loss produces a target that is both unachievable and unnecessary.

33 3gary_naperville, sean_dublin, hannah_MT and 30 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
RunnerRach
Member
467
2,123
Aug 2024
Boston, MA
May 16, 2025 at 12:04 AM#4
marcus_mpls said:
My appetite is suppressed enough that hitting a protein target is now the hardest part of the day, and everything I read assumes I can simply eat…

Can confirm the pattern marcus_mpls describes. Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

32 2jennifer_SEA, tyler_CSCS, VanRx_Mike and 29 others
Reply Quote Save Share Report
roxy_nash
Member
178
890
Dec 2024
Nashville, TN
May 16, 2025 at 2:08 AM#5

From the other side of the consultation, briefly.

DEXA scan update relevant to protein intake:

Scanned at months 0, 6, and 12. Here are the body comp numbers:

BaselineMonth 6Month 12
Total mass247 lbs212 lbs214 lbs
Fat mass117 lbs67 lbs49 lbs
Lean mass155 lbs154 lbs151 lbs
Body fat %40%34%23%

Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The protein intake discussion needs to include body comp data, not just scale weight.

Last edited: May 16, 2025 at 8:08 AM
31 1kim_atl_prep, sarah_TO, wendy_avl and 28 others
Reply Quote Save Share Report

Similar Threads

Protein requirements on GLP-1: systematic review of RDA vs optimal intake8 replies
Micronutrient deficiency risk on GLP-1 — B12, D, iron, zinc, folate10 replies
High-protein meal plans for GLP-1 users — 1500-2000 kcal options9 replies
Meal prep Sunday — weekly high-protein recipes thread9 replies
Creatine monohydrate + GLP-1 — safety and lean mass preservation data14 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register