Dr.EndoIndy said:

Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Coming at Dr.EndoIndy’s question from a different direction. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

One thing that is still open after Dr.EndoIndy’s answer:

How long did you give it before you decided it was working?

TrialTracker_MD said:

Practical: whatever you change, write down the date and the reason.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

Correct me if the detail matters more than I have assumed.

TrialTracker_MD said:

Practical: whatever you change, write down the date and the reason.

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

Worth separating that from cross-border ordering, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.