NurseLeah_Nash said:

The pattern that distinguishes a bad batch from an exit is behaviour rather than product.

This answered a question I did not know how to ask. I will report back once I have actually tried it.

Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

SleepDoc_PDX said:

Shipping damage protocol for vendor vetting orders: if your package arrives with visible damage, temperature excursion, or broken vials: Photograph…

This is where I part company with the consensus forming above. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Ask again with the specifics and you will get a better answer than this one.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.