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ForumsPharmacology & MechanismsPeptide degradation pathways — DPP-4 and NEP 24.11 cleavage sites Page 3

Peptide degradation pathways — DPP-4 and NEP 24.11 cleavage sites

PeptideChemSF Sun, May 31, 2026 at 12:39 PM 18 replies 345 viewsPage 3 of 4
marco_milano
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Jun 1, 2026 at 4:51 PM#11
NurseKim_ATL said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

13 11kevin_tulsa, Dr.PainCLE, mike_mealprep and 10 others
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roxy_nash
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Nashville, TN
Jun 2, 2026 at 10:31 AM#12

From the other side of the consultation, briefly. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

14 12roxy_nash, tony_orlando, Dr.NephBHM_UK and 11 others
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DebRD_ATL
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Jun 3, 2026 at 4:12 AM#13
hans_munich said:
I want to add the drug interaction perspective on the pharmacology.

This is where I part company with the consensus forming above. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Last edited: Jun 3, 2026 at 8:12 AM
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lucas_SP_BR
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Jun 3, 2026 at 9:52 PM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

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mike_mod
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Jun 4, 2026 at 3:31 PM#15

Moderator note: a couple of off-topic posts removed.

Last edited: Jun 4, 2026 at 5:31 PM
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