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ForumsPharmacology & MechanismsGLP-1R allosteric modulators — future of non-peptide agonists Page 2

GLP-1R allosteric modulators — future of non-peptide agonists

PeptideChemSF Tue, May 26, 2026 at 8:01 PM 12 replies 473 viewsPage 2 of 3
lucas_SP_BR
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São Paulo, BR
May 27, 2026 at 12:36 AM#6

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

8 3NurseKim_ATL, paul_denver, TinaHashiRN and 5 others
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steve_okc
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Jul 2024
Oklahoma City, OK
May 27, 2026 at 2:24 AM#7

One thing that is still open after traveltech_sara’s answer:

What did you change at the same time, and can you separate the two now?

7 2JakeSmashed95, NauseaFreeNow, SteveThurs and 4 others
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TinaHashiRN
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Raleigh, NC
May 27, 2026 at 4:12 AM#8
lucas_SP_BR said:
If you are going to change something, change one thing and give it long enough to express itself.

Coming at lucas_SP_BR’s question from a different direction. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

6 1Dr.Martinez, mike_mod, SarahChen_PharmD and 3 others
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PeptideChemSF
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May 27, 2026 at 6:00 AM#9

Reporting back.

Coming back a few months on. It held. Nothing dramatic to report, which is the report.

5 0ricardo_MIA, BrianDallas92, labquiet_amy and 2 others
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stefan_berlin
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Oct 2024
Berlin, DE
May 27, 2026 at 2:37 PM#10
TinaHashiRN said:
It helps to ask what evidence would change your mind before you look at any.

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

45 18TrialTracker_MD, JennaRN, LabKate and 42 others
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