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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsGLP-1R expression map — 12 month update Page 6

GLP-1R expression map — 12 month update

DanielChem_CHI Fri, Apr 17, 2026 at 1:45 PM 28 replies 903 viewsPage 6 of 6
MounjBrad
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May 19, 2026 at 12:30 AM#26
BethLabQueen said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

11 11patPC_UT, Dr.DermMIA, fiona_VT and 8 others
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Dr.PathRoch
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May 23, 2026 at 5:16 AM#27

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

10 10InsuranceTom, WendyG_ATL, SaraMom3 and 7 others
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tane_welly
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May 27, 2026 at 10:00 AM#28
Dr.PathRoch said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Same experience, arrived at from the opposite direction. The detail I would add is minor and it is already implied above.

9 9DanielChem_CHI, marco_milano, pam_columbus and 6 others
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RegAffairsDC
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May 31, 2026 at 2:41 PM#29
Dr.PathRoch said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Adding the part of the answer the thread has not reached. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

8 8sean_dublin, hannah_MT, Dr.SportsMedIN and 5 others
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DanielChem_CHI
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Jun 4, 2026 at 7:20 PM#30

OP back with an update, since a thread like this is useless without one.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.

36 11nick_SD_fit, ben_calgary, patPC_UT and 33 others
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