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ForumsDosing & ProtocolsSplitting doses — 12 month update Page 5

Splitting doses — 12 month update

steph_laguna Sat, Aug 16, 2025 at 5:30 AM 24 replies 1,702 viewsPage 5 of 5
TomFromTexas
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Aug 22, 2025 at 4:29 AM#21

Following on from TrialTracker_MD — and this may be the naive question:

What would you measure differently if you were starting again?

Last edited: Aug 22, 2025 at 6:29 AM
2 2PharmD_Rodriguez, julia.endo
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nancy_portland
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Aug 24, 2025 at 2:24 AM#22
Dr.PulmRoch said:
The version of this that has an answer is narrower than the version being asked.

I read this differently from Dr.PulmRoch, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

That is the short version; the long version is somebody else's post.

1 1KristenIndy
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pete_RVA
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Richmond, VA
Aug 26, 2025 at 12:18 AM#23
Dr.PulmRoch said:
The version of this that has an answer is narrower than the version being asked.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

50 0Admin, Dr.Martinez, mike_mod and 47 others
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greg_boulder
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Aug 27, 2025 at 10:11 PM#24
Dr.PulmRoch said:
The version of this that has an answer is narrower than the version being asked.

Genuinely useful, thank you. I had the facts and not the framework.

49 24patPC_UT, Dr.DermMIA, fiona_VT and 46 others
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anders_CPH
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Aug 29, 2025 at 8:03 PM#25

From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

That is the short version; the long version is somebody else's post.

Last edited: Aug 30, 2025 at 12:03 AM
48 23ChrisMacros, KetoKyle, CanadaChris and 45 others
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