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ForumsPharmacology & MechanismsIncretin effect in healthy vs T2DM — May 2025 Page 2

Incretin effect in healthy vs T2DM — May 2025

CryptoCarl Tue, Mar 10, 2026 at 11:29 PM 6 replies 681 viewsPage 2 of 2
Dr.ReproEndo
Senior Member
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Mar 11, 2026 at 3:04 PM#6
BariatricNurseD said:
My labs after 12 months on glycaemic control: A1C 5.1%, fasting glucose 86 mg/dL, fasting insulin 5 uIU/mL.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1191099587
Insulin (fasting)2517117
HOMA-IR5.53.02.31.3
Uric Acid7.76.96.25.0

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

46 16mona_PHX, andrew_nyc, Dr.EndoEP and 43 others
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PharmacoVig_BOS
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Feb 2024
Boston, MA
Mar 11, 2026 at 9:14 PM#7
CryptoCarl said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

After 7 months: periods became regular for the first time in years, testosterone levels normalized, acne cleared significantly, and — unexpectedly — I got pregnant naturally after 4 years of trying.

GLP-1 agonists address the insulin resistance at the root of PCOS. For PCOS patients, this isn't "just" a weight loss drug — it's treating our underlying metabolic dysfunction.

45 15Dr.GutHealth, amsterdam_pete, LondonLisa and 42 others
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Dr.CardioMD
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Cleveland, OH
Mar 12, 2026 at 3:24 AM#8
Dr.ReproEndo said:
Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone: Test Baseline Month 3 Month 6 Month 12…

Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 38% to 22%. Target is <36%, with <30% being ideal.

Why this matters more than average glucose: large glucose swings cause oxidative stress, endothelial damage, and promote advanced glycation end-products (AGEs). A flat glucose line at 95 mg/dL is metabolically healthier than oscillating between 60 and 160, even if the average is the same.

44 14tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 41 others
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NurseLeah_Nash
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Sep 2024
Nashville, TN
Mar 12, 2026 at 9:34 AM#9

One thing that is still open after Admin’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

43 13Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 40 others
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CryptoCarl
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May 2024
Arizona
Mar 13, 2026 at 3:08 PM#10
Dr.CardioMD said:
Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 38% to 22%.

Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction than glucose or A1C.

My fasting insulin: 24 → 14 → 7 uIU/mL over 9 months. Target is <7. By the time your fasting glucose is elevated, your insulin has been elevated for YEARS trying to compensate.

Ask your doctor to include fasting insulin in your bloodwork panel. It's cheap (~$20) and incredibly informative.

Last edited: Mar 13, 2026 at 7:08 PM
21 19ChrisMacros, KetoKyle, CanadaChris and 18 others
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