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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesMetabolic syndrome reversal criteria — looking for input Page 3

Metabolic syndrome reversal criteria — looking for input

dave_SLC Thu, Apr 30, 2026 at 8:53 AM 20 replies 836 viewsPage 3 of 4
CarlaRPh_TPA
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May 1, 2026 at 11:13 AM#11
NurseAsh_DET said:
Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction…

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Last edited: May 1, 2026 at 3:13 PM
33 6FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 30 others
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JenPlateau
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May 1, 2026 at 7:26 PM#12
mike_nyc said:
Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking: HOMA-IR = (fasting…

This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.

34 7TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 31 others
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Dr.SurgeonPGH
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May 2, 2026 at 3:39 AM#13
NurseAsh_DET said:
Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction…

This is where I part company with the consensus forming above. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Correct me if the detail matters more than I have assumed.

35 8PharmHunterJen, TomTeleRx, DoseLogDan and 32 others
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DoseLogDan
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May 2, 2026 at 11:52 AM#14

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: May 2, 2026 at 12:52 PM
36 9sophie_paris, mel_PDX, Dr.AddMedPHL and 33 others
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Admin
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May 2, 2026 at 8:05 PM#15

Moderator note: a couple of off-topic posts removed.

Last edited: May 3, 2026 at 12:05 AM
37 10PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 34 others
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