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ForumsDosing & ProtocolsMicro-dosing semaglutide — what worked for you? Page 4

Micro-dosing semaglutide — what worked for you?

Dr.NateNeph Sat, Feb 22, 2025 at 9:06 AM 18 replies 1,612 viewsPage 4 of 4
james_edin
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Mar 12, 2025 at 3:50 PM#16

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

41 14mona_PHX, andrew_nyc, Dr.EndoEP and 38 others
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tammy_FL
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Mar 15, 2025 at 7:50 AM#17
james_edin said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

I read this differently from james_edin, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

42 15alex_tucson, kevin_tulsa, Dr.PainCLE and 39 others
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BenResearch_OR
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Mar 17, 2025 at 11:51 PM#18
james_edin said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

43 16Dr.NateNeph, PharmD_Rodriguez, julia.endo and 40 others
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ricardo_MIA
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Mar 20, 2025 at 3:53 PM#19
james_edin said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

44 17KetoKyle, CanadaChris, ZaraB_AL and 41 others
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mike_mod
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Mar 23, 2025 at 7:57 AM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.

16 14PurityPaulOR, MaxMetOK, MounjBrad and 13 others
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