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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsHas anyone dealt with reconstitution calculator? Page 2

Has anyone dealt with reconstitution calculator?

zoe_NC Mon, Jan 20, 2025 at 7:38 AM 34 replies 2,180 viewsPage 2 of 7
hank_denver
Member
278
1,234
Sep 2024
Denver, CO
Jan 20, 2025 at 9:13 AM#6
zoe_NC said:
Concentration choice is a precision decision, not a preference.

Ongoing cost tracking for dosing arithmetic — transparency for the community:

Monthly medication cost: $125
Supplies (syringes, BAC water, alcohol swabs): ~$8/month
Janoshik testing: ~$10/month (amortized quarterly)
Lab work: ~$55/month (amortized quarterly)
Total: ~$195/month

Compare to brand Wegovy at $1215/month without insurance. Compounded is roughly 85% cheaper for what I have found to be clinically equivalent medication.

40 10ingrid_STO, pete_nash, hank_denver and 37 others
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nick_SD_fit
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Sep 2024
San Diego, CA
Jan 20, 2025 at 9:50 AM#7

Following on from DebRD_ATL — and this may be the naive question:

How much material I am losing to dead space, and whether that explains why a 10mg vial gives me nine usable draws rather than ten?

39 9Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 36 others
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Dr.GastroMayo
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Jan 2024
Mayo Clinic, MN
Jan 20, 2025 at 10:27 AM#8
hank_denver said:
Ongoing cost tracking for dosing arithmetic — transparency for the community: Monthly medication cost: $125 Supplies (syringes, BAC water, alcohol…

Quick syringe math for dosing arithmetic dosing: if your vial is reconstituted at 5mg/2mL, that's 2.5mg/mL. For a 0.25mg dose you need 0.1mL = 10 units on an insulin syringe.

I keep a chart on my fridge:

  • 0.25mg = 10 units
  • 0.5mg = 20 units
  • 1.0mg = 40 units
  • 1.25mg = 50 units

Always double-check your concentration before drawing up!

Last edited: Jan 20, 2025 at 3:27 PM
38 8COA_Karl, MikeFit_NJ, InsuranceTom and 35 others
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zoe_NC
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Nov 2024
Charlotte, NC
Jan 20, 2025 at 11:04 AM#9

OP back with an update, since a thread like this is useless without one.

Follow-up: it was dead space. Switching to a low-dead-space fixed-needle syringe gave me the tenth dose back.

37 7NicoleRaleigh, james_edin, FranDenver and 34 others
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FDA_TrackerJim
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Rockville, MD
Jan 20, 2025 at 2:00 PM#10
Dr.GastroMayo said:
Quick syringe math for dosing arithmetic dosing: if your vial is reconstituted at 5mg/2mL, that's 2.5mg/mL.

Agreed, and it is worth saying that rounding to the nearest whole unit is usually acceptable at maintenance doses and is not acceptable at the bottom of a ladder, where one unit can be a fifth of the intended dose.

7 5jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 4 others
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