DebRD_ATL said:

The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Adding the part of the answer the thread has not reached. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Carry on.

josh_phd_bmore said:

If you are going to change something, change one thing and give it long enough to express itself.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

josh_phd_bmore said:

If you are going to change something, change one thing and give it long enough to express itself.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.