CarlaRPh_TPA said:

Sharing my dosing arithmetic titration experience with compounded semaglutide — I have been tracking injection volumes meticulously: Using 5mg/2mL…

Mine went the same way, slower.

CarlaRPh_TPA said:

Sharing my dosing arithmetic titration experience with compounded semaglutide — I have been tracking injection volumes meticulously: Using 5mg/2mL…

Bacteriostatic water quality matters for dosing arithmetic reconstitution. Not all BAC water is created equal:

• Should contain 0.9% benzyl alcohol as preservative
• Must be sterile and pyrogen-free
• Should come in a sealed, intact vial
• Check expiration date — yes, BAC water expires
• Store at room temperature, protected from light

I buy from a reputable medical supply company, not Amazon marketplace sellers. The $3 savings isn't worth the infection risk from unverified BAC water.

CarlaRPh_TPA said:

Sharing my dosing arithmetic titration experience with compounded semaglutide — I have been tracking injection volumes meticulously: Using 5mg/2mL…

Compounding pharmacy dose accuracy check for dosing arithmetic: I always verify my first dose from a new vial by weighing it on a milligram scale. Draw up your dose, weigh the syringe, subtract empty syringe weight, compare to expected water weight at that volume.

For a 10-unit dose (0.1mL): expected weight ~100mg of water. If it's significantly off, your syringe may be inaccurate. Cheap insulin syringes can have ±5% volume accuracy. Spring for quality brands like BD or Terumo.

One thing that is still open after CarlaRPh_TPA’s answer:

What did you change at the same time, and can you separate the two now?

OP back with an update, since a thread like this is useless without one.

Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality changed. I was reading the product and not the behaviour.