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ForumsMetabolic Health & DiabetesBlood sugar used to spike to 200 after meals, now barely hits 120 — what worked for you?

Blood sugar used to spike to 200 after meals, now barely hits 120 — what worked for you?

SallyK_inj Mon, Feb 2, 2026 at 2:16 AM 28 replies 1,338 viewsPage 1 of 6
SallyK_inj
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Jul 2024
Iowa
Feb 2, 2026 at 2:16 AM#1

A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Because it is glucose-dependent, this class carries a low intrinsic hypoglycaemia risk on its own — the risk arrives when it is combined with insulin or a sulfonylurea, which usually need reducing.

What I am trying to establish is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

I would rather have one careful answer than five confident ones.

13 8amy_econ_NJ, bbq_ray_KC, oliver_london and 10 others
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LarryQC_SD
Senior Member
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9,876
Jan 2024
San Diego, CA
Feb 2, 2026 at 4:02 AM#2
SallyK_inj said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

My labs after 3 months on glycaemic control: A1C 5.8%, fasting glucose 83 mg/dL, fasting insulin 6 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 8.1% and fasting glucose was 118 mg/dL. The improvement has been dramatic and consistent.

12 7paul_denver, TinaHashiRN, robert_kc and 9 others
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bri_stats
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May 2024
Seattle, WA
Feb 2, 2026 at 5:48 AM#3
LarryQC_SD said:
My labs after 3 months on glycaemic control: A1C 5.8%, fasting glucose 83 mg/dL, fasting insulin 6 uIU/mL.

Patient selection optimization for glycaemic control: emerging predictive biomarkers for GLP-1 agonist response include:

BiomarkerAssociationEvidence Level
Baseline BMIHigher BMI → greater absolute weight lossStrong
Fasting insulinHigher insulin → better responseModerate
GLP1R gene variantsrs6923761 → variable responsePreliminary
Baseline hsCRPHigher CRP → greater CV benefitModerate
Early weight loss (4 wk)≥3% at 4 wks → strong predictor of ≥10% at 68 wksStrong

The 4-week early responder criterion is the most clinically actionable: if you haven't lost ≥3% by week 4 at a therapeutic dose, discuss optimization strategies with your provider.

Last edited: Feb 2, 2026 at 9:48 AM
11 6TomFromTexas, mike.trainer_LA, sarah_nash92 and 8 others
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pete_nash
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Aug 2024
Nashville, TN
Feb 2, 2026 at 7:34 AM#4
SallyK_inj said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Second this.

10 5SarahChen_PharmD, sarah.morrison, NeuroNate and 7 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
Feb 2, 2026 at 6:01 PM#5

Adding the clinical framing, because it changes how the question reads.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1161069284
Insulin (fasting)221487
HOMA-IR4.54.22.01.5
Uric Acid8.96.65.95.2

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 4.5 to near 1.0 is a metabolic transformation.

Last edited: Feb 3, 2026 at 12:01 AM
9 4Dr.MetabolicMD, RetaRick_CA, JenPlateau and 6 others
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