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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — what worked for you?

Adiponectin and leptin changes on GLP-1 therapy — what worked for you?

bri_stats Mon, Dec 15, 2025 at 5:59 AM 39 replies 1,546 viewsPage 1 of 8
bri_stats
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May 2024
Seattle, WA
Dec 15, 2025 at 5:59 AM#1

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer have my main coping mechanism.

The question I want answered is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Practical detail welcome, however dull — the duller the better.

1 21sarah_nash92
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Dr.NateNeph
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Dec 2023
Houston, TX
Dec 15, 2025 at 6:12 AM#2
bri_stats said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me. Change — even positive change — is stressful. I was anxious about people treating me differently.

This is more common than people admit. A therapist who specializes in weight management has been invaluable. Don't neglect the mental health side of this journey.

50 20NauseaFreeNow, SteveThurs, B12Beth and 47 others
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Dr.LeslieOBGYN
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May 2024
Dallas, TX
Dec 15, 2025 at 6:25 AM#3
Dr.NateNeph said:
Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me.

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

49 19james_edin, FranDenver, Dr.BariatricHTX and 46 others
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AmyNC_wife
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Jun 2024
North Carolina
Dec 15, 2025 at 6:38 AM#4
bri_stats said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Mine went the same way, slower.

48 18Dr.NateNeph, PharmD_Rodriguez, julia.endo and 45 others
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newstart_MO
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Feb 2026
Springfield, MO
Dec 15, 2025 at 7:44 AM#5

Clinical perspective, offered as context rather than as advice.

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 3. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

47 17RunnerRach, TrialNerd_Beth, HPLC_Greg and 44 others
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