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ForumsPharmacology & MechanismsGLP-1R desensitization — 12 month update Page 5

GLP-1R desensitization — 12 month update

WendyG_ATL Sat, Aug 16, 2025 at 8:18 AM 40 replies 1,750 viewsPage 5 of 8
LipidDoc_ATL
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Aug 18, 2025 at 11:20 PM#21

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

16 14rachel_ABQ, traveltech_sara, AttorneyGrant and 13 others
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Dr.LeslieOBGYN
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Dallas, TX
Aug 19, 2025 at 8:39 AM#22
LipidDoc_ATL said:
It is worth asking what the claim would look like if it were false.

Can confirm. Same sequence, different timescale.

17 15FranDenver, Dr.BariatricHTX, LindaRN_retired and 14 others
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DataDave
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Aug 19, 2025 at 5:58 PM#23
LipidDoc_ATL said:
It is worth asking what the claim would look like if it were false.

There is a second half to this that has not been said yet. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

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LabKate
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Aug 20, 2025 at 3:16 AM#24

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

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tammy_FL
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Aug 20, 2025 at 12:34 PM#25

One thing that is still open after LipidDoc_ATL’s answer:

How long did you give it before you decided it was working?

20 18mike_mealprep, NicoleRaleigh, james_edin and 17 others
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