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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsGlucagon receptor signaling — anyone have experience? Page 3

Glucagon receptor signaling — anyone have experience?

AmyNC_wife Fri, Jul 11, 2025 at 11:23 PM 50 replies 2,366 viewsPage 3 of 10
Dr.ReproEndo
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Jul 18, 2025 at 12:41 AM#11
Dr.PulmRoch said:
It helps to say which part of this you are uncertain about.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Last edited: Jul 18, 2025 at 1:41 AM
34 7mona_PHX, andrew_nyc, Dr.EndoEP and 31 others
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MeganSA_TX
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Jul 20, 2025 at 3:58 AM#12
nick_newbie said:
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

35 8julia.endo, JessicaM_2024, TomFromTexas and 32 others
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Dr.ObesityMed
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Jul 22, 2025 at 7:12 AM#13
Dr.PulmRoch said:
It helps to say which part of this you are uncertain about.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Last edited: Jul 22, 2025 at 1:12 PM
36 9SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 33 others
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bri_stats
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Jul 24, 2025 at 10:26 AM#14

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Happy to go further on any of that.

37 10JessicaM_2024, TomFromTexas, mike.trainer_LA and 34 others
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mike_mod
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Jul 26, 2025 at 1:39 PM#15

Moderator note: a couple of off-topic posts removed. Report rather than reply if it drifts again.

Last edited: Jul 26, 2025 at 3:39 PM
38 11PurityPaulOR, MaxMetOK, MounjBrad and 35 others
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