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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsGlucagon receptor signaling — anyone have experience? Page 9

Glucagon receptor signaling — anyone have experience?

AmyNC_wife Fri, Jul 11, 2025 at 11:23 PM 50 replies 2,366 viewsPage 9 of 10
laura_annarbor
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Feb 17, 2026 at 4:22 AM#41
Dr.GastroMayo said:
It helps to ask what evidence would change your mind before you look at any.

This matches mine closely enough to be worth saying so out loud.

27 0labquiet_amy, emily_PDX, Dr.SleepRoch and 24 others
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mike_nyc
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Feb 26, 2026 at 4:05 PM#42
Dr.GastroMayo said:
It helps to ask what evidence would change your mind before you look at any.

There is a second half to this that has not been said yet. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

28 1stefan_berlin, Dr.EM_Chicago, pete_RVA and 25 others
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mike_mod
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Mar 8, 2026 at 3:43 AM#43

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

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greg_boulder
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Mar 17, 2026 at 3:15 PM#44

A narrower follow-up, since the general answer is now clear:

Did your prescriber agree with that reading, and if not what was their objection?

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emma_london
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Mar 27, 2026 at 2:41 AM#45
mike_nyc said:
Start from the measurement rather than the conclusion.

I read this differently from mike_nyc, on substance rather than tone. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.

Last edited: Mar 27, 2026 at 8:41 AM
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