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ForumsPharmacology & MechanismsHas anyone dealt with structure-activity relationships of glp-1 analogs? Page 3

Has anyone dealt with structure-activity relationships of glp-1 analogs?

A1cHero_PHX Wed, Jul 2, 2025 at 7:41 PM 27 replies 1,773 viewsPage 3 of 6
FranDenver
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Jul 4, 2025 at 2:48 AM#11
Dr.PeteFamMed said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

18 16Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 15 others
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Dr.SportsMedIN
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Jul 4, 2025 at 6:53 PM#12

Clinical perspective, offered as context rather than as advice. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

19 17lisa_labSD, adam_van, Dr.SurgeonPGH and 16 others
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LabKate
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Jul 5, 2025 at 10:57 AM#13
LipidDoc_ATL said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

20 18Dr.SleepRoch, laura_annarbor, JenMemphis and 17 others
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TirzTom
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Jul 6, 2025 at 3:01 AM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

21 19SandraNC_45, Dr.EndoIndy, tom_AK and 18 others
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Admin
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Jul 6, 2025 at 7:05 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.

22 20PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 19 others
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