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ForumsOral GLP-1 AgonistsOral GLP-1 pipeline overview — all agents in development Page 3

Oral GLP-1 pipeline overview — all agents in development

TrialTracker_MD Mon, Feb 26, 2024 at 4:00 PM 291 replies 50,237 viewsPage 3 of 20
tony_orlando
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Feb 27, 2024 at 6:06 AM#11
LibrarianMeg said:
Oral semaglutide is absorbed in the stomach with the help of SNAC, which locally raises pH and protects the peptide long enough to cross.

Bookmarking. The distinction being drawn above is the one nobody else makes. Printing the relevant bit and taking it with me.

7 5NauseaFreeNow, SteveThurs, B12Beth and 4 others
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hyun_seoul
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Seoul, KR
Feb 27, 2024 at 12:57 PM#12

Adding the clinical framing, because it changes how the question reads. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

8 6GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 5 others
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LarryQC_SD
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Feb 27, 2024 at 7:48 PM#13
hans_munich said:
The OASIS programme put 50mg oral in the same territory as 2.4mg injectable — around 15% mean weight loss — but it needed a dose 20 times larger to…

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

9 7TinaHashiRN, robert_kc, dan_philly and 6 others
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labquiet_amy
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Cambridge, MA
Feb 28, 2024 at 2:39 AM#14

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

10 8bri_stats, pete_manc_UK, anna.melb_AU and 7 others
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Admin
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Feb 28, 2024 at 9:30 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.

11 9PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 8 others
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