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ForumsMetabolic Health & DiabetesGLP-1 and gluconeogenesis — what worked for you? Page 10

GLP-1 and gluconeogenesis — what worked for you?

matt_MKE Mon, Oct 20, 2025 at 10:35 AM 50 replies 1,666 viewsPage 10 of 10
FDA_TrackerJim
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Apr 24, 2026 at 11:33 PM#46

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

27 0Dr.Martinez, mike_mod, SarahChen_PharmD and 24 others
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matt_MKE
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May 1, 2026 at 2:36 PM#47

Reporting back.

Closing the loop. The answer turned out to depend on the detail I had left out of the opening post, which is a lesson about how to ask rather than about the subject.

28 1Dr.EndoEP, GraceAZ_72, carl_compliance and 25 others
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Dr.NutriCornell
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May 8, 2026 at 5:36 AM#48
matt_MKE said:
The answer turned out to depend on the detail I had left out of the opening post, which is a lesson about how to ask rather than about the subject.

Pushing back on matt_MKE here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

29 2laura_annarbor, JenMemphis, pat_auckland and 26 others
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quinn_sf
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May 14, 2026 at 8:32 PM#49
matt_MKE said:
The answer turned out to depend on the detail I had left out of the opening post, which is a lesson about how to ask rather than about the subject.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: May 15, 2026 at 2:32 AM
30 3andrew_nyc, Dr.EndoEP, GraceAZ_72 and 27 others
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SleepDoc_PDX
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May 21, 2026 at 11:24 AM#50
matt_MKE said:
The answer turned out to depend on the detail I had left out of the opening post, which is a lesson about how to ask rather than about the subject.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

Last edited: May 21, 2026 at 2:24 PM
2 0mel_PDX, Dr.AddMedPHL
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