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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — oral non-peptide GLP-1 Page 4

Orforglipron Phase 3 ATTAIN-1 topline — oral non-peptide GLP-1

TrialTracker_MD Mon, Jun 8, 2026 at 8:45 AM 16 replies 288 viewsPage 4 of 4
Dr.GastroMayo
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Jun 8, 2026 at 5:14 PM#16
PharmHunterJen said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.

12 10mike_nyc, VendorMark, COA_Karl and 9 others
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mike_mealprep
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Jun 8, 2026 at 6:37 PM#17
SleepDoc_PDX said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

There is a second half to this that has not been said yet. The gap between trial results and real-world results is consistent and it is not fraud. Trial participants get titration by protocol, scheduled contact, free drug and dietetic support; removing that infrastructure costs a few percentage points every time it has been measured. When your own curve sits below the published mean, that is the likeliest explanation before anything about you or your material.

13 11newstart_MO, mia_MS2, LeilaHI and 10 others
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Dr.PeteFamMed
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Jun 8, 2026 at 8:00 PM#18

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

14 12LindaRN_retired, tommy_boulder, hyun_seoul and 11 others
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carl_compliance
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Jun 8, 2026 at 9:24 PM#19

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

15 13FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 12 others
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mike_mod
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Jun 8, 2026 at 10:47 PM#20

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

Last edited: Jun 9, 2026 at 12:47 AM
37 10PurityPaulOR, MaxMetOK, MounjBrad and 34 others
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