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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGot off metformin for the first time in 8 years - crying happy tears — need advice Page 5

Got off metformin for the first time in 8 years - crying happy tears — need advice

gary_naperville Wed, Sep 10, 2025 at 9:24 PM 29 replies 1,622 viewsPage 5 of 6
paul_denver
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Sep 27, 2025 at 1:44 AM#21
anders_CPH said:
One practical note: write down what you did and when, before you need it.

Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.

49 22Dr.LeslieOBGYN, MikeNYC_runner and 46 others
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Dr.PulmRoch
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Oct 2, 2025 at 7:43 AM#22

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Oct 2, 2025 at 8:43 AM
50 23traveltech_sara, AttorneyGrant, DebRD_ATL and 47 others
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Dr.ReproEndo
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Oct 7, 2025 at 1:45 PM#23
Dr.PulmRoch said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Same pattern here, and in the same order. Posting only so the count is not one.

1 24Dr.EndoEP
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SaraMom3
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Oct 12, 2025 at 7:50 PM#24
Dr.PulmRoch said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Adding the part of the answer the thread has not reached. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

2 0CanadaChris, ZaraB_AL
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kate.chem
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Oct 18, 2025 at 1:58 AM#25

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

3 1Dr.RaviCardio, jennifer_SEA, tyler_CSCS
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