Following on from sarah_TO — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

Dr.BariatricHTX said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Dr.BariatricHTX said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

That is the short version; the long version is somebody else's post.

Dr.BariatricHTX said:

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

This answered a question I did not know how to ask.

Clinical perspective, offered as context rather than as advice. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.