🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGLP-1 and insulin resistance — my results so far

GLP-1 and insulin resistance — my results so far

sophie_paris Fri, Aug 8, 2025 at 12:19 AM 16 replies 1,582 viewsPage 1 of 4
This thread is more than 10 months old. Information may be outdated. Consider searching for more recent discussions.
sophie_paris
Member
212
890
Nov 2024
Paris, FR
Aug 8, 2025 at 12:19 AM#1

A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

What I am after is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

Numbers rather than impressions, if you have them.

35 5SallyK_inj, CryptoCarl, MariaRD and 32 others
Reply Quote Save Share Report
Dr.SportsMedIN
Senior Member
1,456
6,789
Feb 2024
Indianapolis, IN
Aug 8, 2025 at 12:28 AM#2
sophie_paris said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 38% to 18%. Target is <36%, with <30% being ideal.

Why this matters more than average glucose: large glucose swings cause oxidative stress, endothelial damage, and promote advanced glycation end-products (AGEs). A flat glucose line at 95 mg/dL is metabolically healthier than oscillating between 60 and 160, even if the average is the same.

Last edited: Aug 8, 2025 at 5:28 AM
34 4lisa_labSD, adam_van, Dr.SurgeonPGH and 31 others
Reply Quote Save Share Report
patPC_UT
Member
212
890
Nov 2024
Park City, UT
Aug 8, 2025 at 12:37 AM#3
Dr.SportsMedIN said:
Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 38% to 18%.

Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction than glucose or A1C.

My fasting insulin: 24 → 12 → 7 uIU/mL over 9 months. Target is <7. By the time your fasting glucose is elevated, your insulin has been elevated for YEARS trying to compensate.

Ask your doctor to include fasting insulin in your bloodwork panel. It's cheap (~$20) and incredibly informative.

Last edited: Aug 8, 2025 at 5:37 AM
33 3TomFromTexas, mike.trainer_LA, sarah_nash92 and 30 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
ZaraB_AL
Member
456
1,678
Jan 2025
Alabama
Aug 8, 2025 at 12:46 AM#4
sophie_paris said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Same experience, arrived at from the opposite direction. The detail I would add is minor and it is already implied above.

32 2TrialTracker_MD, JennaRN, LabKate and 29 others
Reply Quote Save Share Report
chris_chi24
Member
389
1,678
Sep 2024
Chicago, IL
Aug 8, 2025 at 1:30 AM#5

Adding the clinical framing, because it changes how the question reads.

My labs after 9 months on glycaemic control: A1C 5.3%, fasting glucose 93 mg/dL, fasting insulin 4 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 8.1% and fasting glucose was 128 mg/dL. The improvement has been dramatic and consistent.

31 1SleepFixSam, PurityPaulOR, MaxMetOK and 28 others
Reply Quote Save Share Report

Similar Threads

SUSTAIN-6 to SELECT — the cardiovascular evidence timeline14 replies
GLP-1 and insulin resistance — HOMA-IR improvement data17 replies
Metabolic syndrome reversal criteria — how GLP-1 addresses all 55 replies
A1C target achievement rates — sema vs tirz comparison8 replies
SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register