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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism Page 5

Orforglipron and hepatic first-pass metabolism

SarahChen_PharmD Thu, Jun 4, 2026 at 7:28 AM 22 replies 441 viewsPage 5 of 5
PharmD_Rodriguez
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Jun 5, 2026 at 10:17 PM#21

One thing that is still open after newstart_MO’s answer:

What did you change at the same time, and can you separate the two now?

Last edited: Jun 6, 2026 at 3:17 AM
2 0paul_denver, TinaHashiRN
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PharmacoVig_BOS
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Jun 6, 2026 at 2:27 PM#22
LindaRN_retired said:
Worth answering the question that was asked rather than the one behind it.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Jun 6, 2026 at 5:27 PM
3 1Dr.GutHealth, amsterdam_pete, LondonLisa
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adam_van
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Jun 7, 2026 at 6:38 AM#23
LindaRN_retired said:
Worth answering the question that was asked rather than the one behind it.

No disagreement with LindaRN_retired. One condition attached. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Last edited: Jun 7, 2026 at 10:38 AM
4 2LindaRN_retired, tommy_boulder, hyun_seoul and 1 other
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InsuranceTom
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Jun 7, 2026 at 10:49 PM#24
LindaRN_retired said:
Worth answering the question that was asked rather than the one behind it.

Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.

5 3matt_MKE, Dr.ReproEndo, lucas_SP_BR and 2 others
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Dr.ObesityMed
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Jun 8, 2026 at 3:00 PM#25

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

6 4A1cHero_PHX, Dr.RenalNash, LipidDoc_ATL and 3 others
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