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ForumsOral GLP-1 AgonistsRybelsus real-world vs clinical trial efficacy — the gap explained Page 5

Rybelsus real-world vs clinical trial efficacy — the gap explained

BiostatsBrad Thu, May 21, 2026 at 5:35 AM 23 replies 904 viewsPage 5 of 5
dan_philly
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May 24, 2026 at 4:50 AM#21

One concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

31 4DadBodDave, AmyNC_wife, SkepticalSean and 28 others
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RetaRick_CA
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May 25, 2026 at 12:04 AM#22

Following on from PharmacoVig_BOS — and this may be the naive question:

How to read a result like this without either dismissing it or over-reading it, since the summaries all read like press releases?

32 5AmyNC_wife, SkepticalSean, Dr.CardioMD and 29 others
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AussieAnna
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May 25, 2026 at 7:17 PM#23
dan_philly said:
Keep the original post as written when you update it, and add the correction underneath.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Last edited: May 25, 2026 at 8:17 PM
33 6LibrarianMeg, bri_stats, pete_manc_UK and 30 others
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fiona_glasgow
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May 26, 2026 at 2:30 PM#24
dan_philly said:
Keep the original post as written when you update it, and add the correction underneath.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Last edited: May 26, 2026 at 7:30 PM
34 7JessicaH_TX, KevinCompounds, TirzTom and 31 others
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PeptideSynthNJ
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Aug 2024
Princeton, NJ
May 27, 2026 at 9:42 AM#25
dan_philly said:
Keep the original post as written when you update it, and add the correction underneath.

That reframing is the part I needed. Taking it to my next appointment.

35 8Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 32 others
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