🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsHas anyone dealt with glp-1r expression map? Page 6

Has anyone dealt with glp-1r expression map?

mike_mod Fri, Oct 18, 2024 at 7:09 PM 35 replies 1,913 viewsPage 6 of 7
wendy_avl
Member
245
1,123
Oct 2024
Asheville, NC
Nov 15, 2024 at 4:34 PM#26
Dr.AddMedPHL said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Pushing back on Dr.AddMedPHL here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Last edited: Nov 15, 2024 at 10:34 PM
47 20SleepFixSam, PurityPaulOR, MaxMetOK and 44 others
Reply Quote Save Share Report
hans_munich
Member
534
2,345
Jul 2024
Munich, DE
Nov 19, 2024 at 5:49 AM#27
Dr.AddMedPHL said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Last edited: Nov 19, 2024 at 11:49 AM
48 21alex_tucson, kevin_tulsa, Dr.PainCLE and 45 others
Reply Quote Save Share Report
raj_cambridge
Member
489
2,123
Jun 2024
Cambridge, MA
Nov 22, 2024 at 7:02 PM#28
Dr.AddMedPHL said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.

Last edited: Nov 22, 2024 at 8:02 PM
49 22TomTeleRx, DoseLogDan, SleepFixSam and 46 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
VendorMark
Senior Member
3,456
14,567
Jan 2024
Texas
Online
Nov 26, 2024 at 8:13 AM#29

Adding the clinical framing, because it changes how the question reads. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

50 23Dr.PeteFamMed, claudia_zurich, nancy_portland and 47 others
Reply Quote Save Share Report
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
Nov 29, 2024 at 9:22 PM#30

Reporting back.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.

Last edited: Nov 29, 2024 at 11:22 PM
22 20PurityPaulOR, MaxMetOK, MounjBrad and 19 others
Reply Quote Save Share Report

Similar Threads

GLP-1R desensitization — β-arrestin-mediated internalization18 replies
Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register