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ForumsOral GLP-1 AgonistsOrforglipron Phase 2 weight loss data — 14.7% at 36 weeks Page 3

Orforglipron Phase 2 weight loss data — 14.7% at 36 weeks

TrialNerd_Beth Thu, May 14, 2026 at 7:12 AM 17 replies 639 viewsPage 3 of 4
SteveThurs
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May 19, 2026 at 7:26 PM#11
Dr.LeslieOBGYN said:
The manufacturing argument is the underrated one.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

4 2MaxMetOK, MounjBrad, nick_newbie and 1 other
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andrew_nyc
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May 20, 2026 at 2:36 AM#12

Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Last edited: May 20, 2026 at 7:36 AM
5 3Dr.NateNeph, PharmD_Rodriguez, julia.endo and 2 others
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InsuranceTom
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May 20, 2026 at 9:46 AM#13
Dr.PathRoch said:
The gap between trial results and real-world results is consistent and it is not fraud.

Pushing back on Dr.PathRoch here. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

6 4Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 3 others
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Dr.GutHealth
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May 20, 2026 at 4:56 PM#14

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

That is the short version; the long version is somebody else's post.

Last edited: May 20, 2026 at 9:56 PM
7 5Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 4 others
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mike_mod
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May 21, 2026 at 12:06 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.

Last edited: May 21, 2026 at 2:06 AM
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