From the other side of the consultation, briefly. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.
bri_stats said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.
Clinical perspective, offered as context rather than as advice. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
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Browse GL BiochemPedsEndoPhilly said:It is worth asking what the claim would look like if it were false.
Same position here, arrived at the long way round. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.