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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 7

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 7 of 10
james_edin
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Jul 26, 2024 at 6:13 PM#31
Dr.RaviCardio said:
The version of this that has an answer is narrower than the version being asked.

Adding the part of the answer the thread has not reached. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Last edited: Jul 26, 2024 at 8:13 PM
23 21mona_PHX, andrew_nyc, Dr.EndoEP and 20 others
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Dr.AddMedPHL
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Jul 27, 2024 at 1:36 AM#32

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

24 22sarah_nash92, FitDadDave, RunnerRach and 21 others
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NauseaFreeNow
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Jul 27, 2024 at 8:59 AM#33

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

Last edited: Jul 27, 2024 at 12:59 PM
25 23Dr.PulmRoch, maya_sedona, stefan_berlin and 22 others
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sarah_TO
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Jul 27, 2024 at 4:22 PM#34
Dr.AddMedPHL said:
If you are going to change something, change one thing and give it long enough to express itself.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

26 24carl_compliance, DanielChem_CHI, marco_milano and 23 others
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jim_asheville
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Jul 27, 2024 at 11:44 PM#35
Dr.AddMedPHL said:
If you are going to change something, change one thing and give it long enough to express itself.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Last edited: Jul 28, 2024 at 2:44 AM
27 0LarryQC_SD, wanda_boise, NurseAsh_DET and 24 others
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