One thing that is still open after Dr.NateNeph’s answer:

What would you measure differently if you were starting again?

jason_paloalto said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

I read this differently from jason_paloalto, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.

jason_paloalto said:

For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.