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ForumsPharmacology & MechanismsWhy does it stop working after a while for some people — what worked for you? Page 3

Why does it stop working after a while for some people — what worked for you?

Dr.ObesityLA Thu, May 2, 2024 at 3:42 PM 19 replies 2,021 viewsPage 3 of 4
labquiet_amy
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May 4, 2024 at 1:25 AM#11
claudia_zurich said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

Last edited: May 4, 2024 at 3:25 AM
45 18TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 42 others
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laura_annarbor
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Ann Arbor, MI
May 5, 2024 at 3:39 AM#12
InsuranceTom said:
The pharmacokinetics explain nearly every practical question asked here.

Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.

46 19emily_PDX, Dr.SleepRoch, laura_annarbor and 43 others
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zoe_NC
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Nov 2024
Charlotte, NC
May 6, 2024 at 5:53 AM#13
claudia_zurich said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

Last edited: May 6, 2024 at 6:53 AM
47 20james_edin, FranDenver, Dr.BariatricHTX and 44 others
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SleepDoc_PDX
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May 7, 2024 at 8:06 AM#14

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

48 21sophie_paris, mel_PDX, Dr.AddMedPHL and 45 others
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mike_mod
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May 8, 2024 at 10:19 AM#15

Moderator note: a couple of off-topic posts removed.

49 22PurityPaulOR, MaxMetOK, MounjBrad and 46 others
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