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ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — 12 month update Page 2

Adiponectin and leptin changes on GLP-1 therapy — 12 month update

Dr.PathRoch Sun, Oct 6, 2024 at 8:34 PM 12 replies 1,878 viewsPage 2 of 3
dan_philly
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Oct 7, 2024 at 7:25 AM#6
Dr.PathRoch said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

16 11DadBodDave, AmyNC_wife, SkepticalSean and 13 others
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VanRx_Mike
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May 2024
Vancouver, CA
Oct 7, 2024 at 11:41 AM#7

One thing that is still open after TinaHashiRN’s answer:

What would you measure differently if you were starting again?

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roxy_nash
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Nashville, TN
Oct 7, 2024 at 3:57 PM#8
dan_philly said:
Positive side effects of mental health that surprised me: Clearer skin — inflammation reduction improved my rosacea Better sleep — weight loss…

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

14 9tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 11 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
Oct 7, 2024 at 8:13 PM#9

OP back with an update, since a thread like this is useless without one.

Update: I got the sleep and the intake sorted before deciding it was the drug, and most of the flatness went with them. Not all of it, and I am watching the rest.

Last edited: Oct 8, 2024 at 2:13 AM
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sean_dublin
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Dublin, IE
Oct 8, 2024 at 4:42 PM#10
roxy_nash said:
Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming…

Before/after narrative for mental health — one year in:

Before (258 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (193 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 73 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

Last edited: Oct 8, 2024 at 5:42 PM
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