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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — need advice Page 3

Biased agonism at GLP-1R — need advice

kevin_tulsa Thu, Feb 22, 2024 at 12:00 AM 12 replies 2,101 viewsPage 3 of 3
BenResearch_OR
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Feb 25, 2024 at 9:53 AM#11
Dr.GastroMayo said:
I want to add the drug interaction perspective on the pharmacology.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Ask again with the specifics and you will get a better answer than this one.

20 20julia.endo, JessicaM_2024, TomFromTexas and 17 others
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fiona_glasgow
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Glasgow, UK
Feb 25, 2024 at 11:50 PM#12
Dr.NephBHM_UK said:
The mechanism is more central than most summaries suggest.

This answered a question I did not know how to ask. Taking it to my next appointment.

19 19TirzTom, TrialTracker_MD, JennaRN and 16 others
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jason_paloalto
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Feb 26, 2024 at 1:47 PM#13
Dr.GastroMayo said:
I want to add the drug interaction perspective on the pharmacology.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

Happy to go further on any of that.

Last edited: Feb 26, 2024 at 6:47 PM
18 18mona_PHX, andrew_nyc, Dr.EndoEP and 15 others
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LabKate
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Feb 27, 2024 at 3:45 AM#14

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Last edited: Feb 27, 2024 at 6:45 AM
17 17emily_PDX, Dr.SleepRoch, laura_annarbor and 14 others
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mike_mod
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Feb 27, 2024 at 5:43 PM#15

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.

16 16PurityPaulOR, MaxMetOK, MounjBrad and 13 others
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