anna.melb_AU said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Dr.RaviCardio said:

Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…

Genuinely useful, thank you. I had the facts and not the framework.

anna.melb_AU said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

This is where I part company with the consensus forming above. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Carry on.