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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHas anyone dealt with attain-2: orforglipron in t2dm? Page 5

Has anyone dealt with attain-2: orforglipron in t2dm?

LipidDoc_ATL Thu, Feb 19, 2026 at 5:55 AM 25 replies 1,000 viewsPage 5 of 5
SarahChen_PharmD
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Feb 26, 2026 at 12:11 AM#21

From the other side of the consultation, briefly. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

50 0Dr.ObesityLA, NurseKim_ATL, paul_denver and 47 others
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sean_dublin
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Feb 27, 2026 at 2:56 PM#22
SarahChen_PharmD said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Second this.

49 24sean_dublin, hannah_MT, Dr.SportsMedIN and 46 others
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MikeNYC_runner
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Mar 1, 2026 at 5:42 AM#23
SarahChen_PharmD said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Worth separating that from glycaemic control, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Happy to go further on any of that.

48 23Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 45 others
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hank_denver
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Mar 2, 2026 at 8:29 PM#24

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

47 22fiona_VT, denise_HTX, raj_cambridge and 44 others
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AttorneyGrant
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Mar 4, 2026 at 11:17 AM#25

One thing that is still open after SarahChen_PharmD’s answer:

How would you tell the difference between that and the alternative explanation?

46 21Dr.GastroMayo, JakeBK_lifts, DerekSJ_a1c and 43 others
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