🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesPrediabetes reversal on GLP-1 — what worked for you?

Prediabetes reversal on GLP-1 — what worked for you?

MariaRD Thu, May 30, 2024 at 8:51 AM 47 replies 2,239 viewsPage 1 of 10
This thread is more than 24 months old. Information may be outdated. Consider searching for more recent discussions.
MariaRD
Member
823
4,567
Jun 2024
New Mexico
May 30, 2024 at 8:51 AM#1

A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Because it is glucose-dependent, this class carries a low intrinsic hypoglycaemia risk on its own — the risk arrives when it is combined with insulin or a sulfonylurea, which usually need reducing.

What I actually want to know is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

I have searched first, so if this is covered somewhere point me at it and I will read it.

50 20Dr.NutriCornell, pam_stl, wei_SG and 47 others
Reply Quote Save Share Report
TrialTracker_MD
Senior Member
2,345
15,678
Jan 2024
Maryland
May 30, 2024 at 9:18 AM#2
MariaRD said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

My labs after 3 months on glycaemic control: A1C 5.6%, fasting glucose 91 mg/dL, fasting insulin 4 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 7.7% and fasting glucose was 116 mg/dL. The improvement has been dramatic and consistent.

49 19stefan_berlin, Dr.EM_Chicago, pete_RVA and 46 others
Reply Quote Save Share Report
stefan_berlin
Member
234
1,123
Oct 2024
Berlin, DE
May 30, 2024 at 9:45 AM#3
TrialTracker_MD said:
My labs after 3 months on glycaemic control: A1C 5.6%, fasting glucose 91 mg/dL, fasting insulin 4 uIU/mL.

Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking:

HOMA-IR = (fasting insulin × fasting glucose) ÷ 405

My numbers: Baseline HOMA-IR = 4.3 (insulin resistant) → Current = 1.1 (insulin sensitive)

Anything above 2.0 indicates insulin resistance. The goal is below 1.5. GLP-1 agonists address the root metabolic dysfunction, not just the symptoms. This is why they work so much better than calorie restriction alone.

48 18KevinCompounds, TirzTom, TrialTracker_MD and 45 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
LondonLisa
Member
912
3,456
Mar 2024
London, UK
May 30, 2024 at 10:12 AM#4
MariaRD said:
A1C went from 7.4 to 5.6 over nine months and my prescriber was more interested in the fasting insulin, which I did not expect.

Mine went the same way, slower.

Last edited: May 30, 2024 at 12:12 PM
47 17JenPlateau, SallyK_inj, CryptoCarl and 44 others
Reply Quote Save Share Report
sophie_paris
Member
212
890
Nov 2024
Paris, FR
May 30, 2024 at 12:37 PM#5

Clinical perspective, offered as context rather than as advice.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1171038987
Insulin (fasting)231797
HOMA-IR5.53.31.71.1
Uric Acid8.06.75.64.8

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

46 16BethLabQueen, ChrisMacros, KetoKyle and 43 others
Reply Quote Save Share Report

Similar Threads

SUSTAIN-6 to SELECT — the cardiovascular evidence timeline14 replies
GLP-1 and insulin resistance — HOMA-IR improvement data17 replies
Metabolic syndrome reversal criteria — how GLP-1 addresses all 55 replies
A1C target achievement rates — sema vs tirz comparison8 replies
SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register