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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralThe psychological adjustment to rapid weight loss Page 2

The psychological adjustment to rapid weight loss

AmyNC_wife Sat, Jun 6, 2026 at 9:56 PM 19 replies 235 viewsPage 2 of 4
BenResearch_OR
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Jun 7, 2026 at 4:38 AM#6
FDA_TrackerJim said:
AmyNC_wife said: ...mental health should only be used alongside therapy...

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

28 23julia.endo, JessicaM_2024, TomFromTexas and 25 others
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PharmacoVig_BOS
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Jun 7, 2026 at 7:16 AM#7
AmyNC_wife said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

I have a history of binge eating disorder. My psychiatrist, therapist, and prescribing doctor all collaborate on my care. The GLP-1 agonist has actually been therapeutic — it removes the biological urgency of binge impulses without relying on restriction.

This is NOT appropriate for all ED patients. Anorexia, bulimia, and restrictive EDs require different approaches. But for BED specifically, the evidence and my personal experience are positive. Always involve your mental health team.

27 22Dr.GutHealth, amsterdam_pete, LondonLisa and 24 others
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DebRD_ATL
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Jun 7, 2026 at 9:55 AM#8
BenResearch_OR said:
I would be careful about how confidently the flatness reports get attributed.

Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me. Change — even positive change — is stressful. I was anxious about regaining weight.

This is more common than people admit. A therapist who specializes in weight management has been invaluable. Don't neglect the mental health side of this journey.

26 21SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 23 others
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B12Beth
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Jun 7, 2026 at 12:34 PM#9

One thing that is still open after sarah_nash92’s answer:

How would you tell the difference between that and the alternative explanation?

25 20marco_milano, pam_columbus, nick_SD_fit and 22 others
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AmyNC_wife
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Jun 8, 2026 at 1:16 AM#10

OP back with an update, since a thread like this is useless without one.

Update: I got the sleep and the intake sorted before deciding it was the drug, and most of the flatness went with them. Not all of it, and I am watching the rest.

49 24Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 46 others
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