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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralTherapy + GLP-1 = the combination nobody talks about enough Page 3

Therapy + GLP-1 = the combination nobody talks about enough

SaraMom3 Thu, Jun 4, 2026 at 11:03 AM 20 replies 513 viewsPage 3 of 4
Dr.AddMedPHL
Senior Member
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Mar 2024
Philadelphia, PA
Jun 5, 2026 at 1:46 AM#11
chris_chi24 said:
JennaRN said: ...mental health should only be used alongside therapy...

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
15 15FitDadDave, RunnerRach, TrialNerd_Beth and 12 others
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tammy_FL
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Tampa, FL
Jun 5, 2026 at 11:17 AM#12
BenResearch_OR said:
Before/after narrative for mental health — one year in: Before (267 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications,…

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Sending this to two other people who asked me the same thing last week.

14 14alex_tucson, kevin_tulsa, Dr.PainCLE and 11 others
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RegAffairsDC
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Washington, DC
Jun 5, 2026 at 8:48 PM#13
chris_chi24 said:
JennaRN said: ...mental health should only be used alongside therapy...

Body image adjustment with mental health: I've lost 72 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

13 13hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 10 others
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PharmacoVig_BOS
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Boston, MA
Jun 6, 2026 at 6:19 AM#14
SaraMom3 said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 4. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.

Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.

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Admin
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Jun 6, 2026 at 3:49 PM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.

11 11PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 8 others
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