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ForumsMetabolic Health & DiabetesGLP-1 and insulin resistance — January 2024

GLP-1 and insulin resistance — January 2024

FitDadDave Thu, Feb 22, 2024 at 7:46 AM 8 replies 1,997 viewsPage 1 of 2
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FitDadDave
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Jul 2024
Minneapolis, MN
Feb 22, 2024 at 7:46 AM#1

Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

What would genuinely help is knowing why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

Not looking for reassurance. Looking for the part I have got wrong.

9 4Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 6 others
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labquiet_amy
Senior Member
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Mar 2024
Cambridge, MA
Feb 22, 2024 at 8:42 AM#2
FitDadDave said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1301049482
Insulin (fasting)2612105
HOMA-IR4.53.12.21.4
Uric Acid7.87.06.15.1

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 4.5 to near 1.0 is a metabolic transformation.

Last edited: Feb 22, 2024 at 10:42 AM
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Dr.PainCLE
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Mar 2024
Cleveland, OH
Feb 22, 2024 at 9:38 AM#3
labquiet_amy said:
Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone: Test Baseline Month 3 Month 6 Month 12…

PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

After 7 months: periods became regular for the first time in years, testosterone levels normalized, acne cleared significantly, and — unexpectedly — I got pregnant naturally after 4 years of trying.

GLP-1 agonists address the insulin resistance at the root of PCOS. For PCOS patients, this isn't "just" a weight loss drug — it's treating our underlying metabolic dysfunction.

Last edited: Feb 22, 2024 at 12:38 PM
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emily_PDX
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Nov 2024
Portland, OR
Feb 22, 2024 at 10:34 AM#4
FitDadDave said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

Same experience, arrived at from the opposite direction. Posting only so the count is not one.

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Dr.RenalNash
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Mar 2024
Nashville, TN
Feb 22, 2024 at 3:53 PM#5

From the other side of the consultation, briefly.

My labs after 12 months on glycaemic control: A1C 6.2%, fasting glucose 82 mg/dL, fasting insulin 7 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 7.9% and fasting glucose was 137 mg/dL. The improvement has been dramatic and consistent.

Last edited: Feb 22, 2024 at 8:53 PM
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