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ForumsMetabolic Health & DiabetesA1C target achievement rates — my results so far

A1C target achievement rates — my results so far

zoe_NC Wed, Jan 24, 2024 at 4:35 AM 14 replies 2,274 viewsPage 1 of 3
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zoe_NC
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Charlotte, NC
Jan 24, 2024 at 4:35 AM#1

Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

What I am trying to establish is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner.

Not looking for reassurance. Looking for the part I have got wrong.

50 20Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 47 others
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JennaRN
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Jan 24, 2024 at 5:21 AM#2
zoe_NC said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

My labs after 6 months on glycaemic control: A1C 5.1%, fasting glucose 76 mg/dL, fasting insulin 5 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 6.7% and fasting glucose was 111 mg/dL. The improvement has been dramatic and consistent.

Last edited: Jan 24, 2024 at 6:21 AM
49 19PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 46 others
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JakeSmashed95
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Jan 24, 2024 at 6:07 AM#3
JennaRN said:
My labs after 6 months on glycaemic control: A1C 5.1%, fasting glucose 76 mg/dL, fasting insulin 5 uIU/mL.

Patient selection optimization for glycaemic control: emerging predictive biomarkers for GLP-1 agonist response include:

BiomarkerAssociationEvidence Level
Baseline BMIHigher BMI → greater absolute weight lossStrong
Fasting insulinHigher insulin → better responseModerate
GLP1R gene variantsrs6923761 → variable responsePreliminary
Baseline hsCRPHigher CRP → greater CV benefitModerate
Early weight loss (4 wk)≥3% at 4 wks → strong predictor of ≥10% at 68 wksStrong

The 4-week early responder criterion is the most clinically actionable: if you haven't lost ≥3% by week 4 at a therapeutic dose, discuss optimization strategies with your provider.

48 18alex_tucson, kevin_tulsa, Dr.PainCLE and 45 others
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jason_paloalto
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Palo Alto, CA
Jan 24, 2024 at 6:53 AM#4
zoe_NC said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

Adding a me-too, because a thread of one person's experience is not much use.

Last edited: Jan 24, 2024 at 11:53 AM
47 17andrew_nyc, Dr.EndoEP, GraceAZ_72 and 44 others
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TrialNerd_Beth
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Bethesda, MD
Jan 24, 2024 at 11:14 AM#5

Clinical perspective, offered as context rather than as advice.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)117998983
Insulin (fasting)231396
HOMA-IR5.53.81.71.1
Uric Acid8.56.75.64.8

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

46 16SleepFixSam, PurityPaulOR, MaxMetOK and 43 others
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