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ForumsOral GLP-1 AgonistsOral vs injectable GLP-1: bioavailability and efficacy comparison — anyone have experience? Page 3

Oral vs injectable GLP-1: bioavailability and efficacy comparison — anyone have experience?

stefan_berlin Tue, Nov 18, 2025 at 5:28 PM 45 replies 2,165 viewsPage 3 of 9
amsterdam_pete
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Nov 19, 2025 at 10:05 AM#11
Dr.ObesityMed said:
I want to add the drug interaction perspective on the pharmacology.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

47 22JakeSmashed95, NauseaFreeNow, SteveThurs and 44 others
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dan_philly
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Nov 19, 2025 at 8:38 PM#12
PeptideSynthNJ said:
The mechanism is more central than most summaries suggest.

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

Last edited: Nov 19, 2025 at 11:38 PM
46 21AmyNC_wife, SkepticalSean, Dr.CardioMD and 43 others
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anna.melb_AU
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Nov 20, 2025 at 7:11 AM#13
Dr.ObesityMed said:
I want to add the drug interaction perspective on the pharmacology.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

45 20emma_london, tammy_FL, Dr.LipidDallas and 42 others
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HPLC_Greg
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Nov 20, 2025 at 5:44 PM#14

The figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Last edited: Nov 20, 2025 at 11:44 PM
44 19Dr.MetabolicMD, RetaRick_CA, JenPlateau and 41 others
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mike_mod
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Nov 21, 2025 at 4:17 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

43 18PurityPaulOR, MaxMetOK, MounjBrad and 40 others
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