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ForumsOral GLP-1 AgonistsOral vs injectable GLP-1: bioavailability and efficacy comparison — anyone have experience? Page 7

Oral vs injectable GLP-1: bioavailability and efficacy comparison — anyone have experience?

stefan_berlin Tue, Nov 18, 2025 at 5:28 PM 45 replies 2,165 viewsPage 7 of 9
JessicaH_TX
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Dec 10, 2025 at 6:00 AM#31
Dr.MetabolicMD said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at Dr.MetabolicMD’s question from a different direction. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

35 10wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 32 others
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labquiet_amy
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Dec 11, 2025 at 9:49 PM#32

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Last edited: Dec 11, 2025 at 11:49 PM
34 9HPLC_Greg, LibrarianMeg, bri_stats and 31 others
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SallyK_inj
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Dec 13, 2025 at 1:38 PM#33

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

33 8oliver_london, tane_welly, Dr.PathRoch and 30 others
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sarah.morrison
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Dec 15, 2025 at 5:28 AM#34
labquiet_amy said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

32 7Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 29 others
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JakeSmashed95
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Dec 16, 2025 at 9:19 PM#35
labquiet_amy said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

31 6tammy_FL, Dr.LipidDallas, alex_tucson and 28 others
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